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Genotype
likelihoods Validation
This page contains some videos which demonstrate how to use FamLink and
also Frequently Asked Questions.
Q: Can FamLink account for mutations?
A: Yes, for the pre-defined pedigrees we have implemented a slower
algorithm that can handle mutations for linked markers. Please note that
mutations and genotype likelihoods cannot be modeled simultaneously.
Q: Can FamLink handle multiple linked markers?
A: Yes, the software can handle virtually any number of linked markers.
Please keep in mind that LD (allelic association) is not modeled. We recommend
at least 0.5 cM distance between adjacent markers.
Q: Will FamLink provide the possibility to handle X-chromosomal markers?
A: Yes, in future releases we will extend the software with this option.
X-chromosomal marker can be imported into the software but are currently not
used in any functions/computations.
Q: Will FamLink provide the possibility to handle Y-chromosomal markers?
A: The software can import any data, but Y-chromosomal data is currently
only used to predict haplotypes.
Installation – Video demonstrating how to install FamLink
Video 1 at Youtube
Video 1 in .wmv format
Getting started – Introduction to using FamLink demonstrating how to
setup the Getting started example and do likelihood calculations.
Installing FamLink on some Windows7 machines may experience problems
with permissions – This is a known bug and future releases of FamLink will
hopefully contain a work-around for this issue. Video shows how to set
permissions for the FamLink software.
Video 3 at Youtube
Video 3 in .wmv format
You may send comments to daniel.kling@rmv.se